Insulin-like Growth Factor-binding Protein 3 (IGFBP-3) Blood Test

Test #140152The insulin-like growth factor (IGF) system plays a critical role in the growth and differentiation of normal and malignant cells. The components of the IGF system include growth hormone (GH), IGF-I and II, type I and II receptors, IGF binding proteins and proteases. IGF binding proteins were first identified for their high affinity interactions with IGF-I and IGF-II.2IGFBP-3 is the most abundant IGFBP species in circulation and binds 75% to 90% of circulating IGF-I in a ternary complex consisting of IGFBP-3, IGF-I and acid-labile subunit (ALS). IGFBP-3 modulates the activity of IGF-1 and to increase their half lives. It has been postulated that IGFBP-3 is regulated by GH and originates in the liver as low levels were observed in patients with impaired hepatic function.3IGFBP-3 has historically been used in the investigation of growth hormone deficiency, acromegaly, hypopituitarism and to monitor recombinant GH therapy.4,5 IGFBP-3 is known to modulate the actions of IGFs in circulation as and at the IGF-1 receptor.3 IGFBP-3 has also been shown to exhibit distinct biological effects independent of the IGF/IGF-1 receptor axis.6,7 Recent studies have impaired interaction of IGFBP-3 with a variety of proteins or signaling cascades critical to cell cycle control and apoptosis; however, the actual mechanism of IGFBP-3 action is unclear.6

Preparation:

No fasting required

Test Type: Blood

Test Results: 3-4 days

Baxter RC, Martin JL. Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma.

J Clin Invest.

1986 Dec; 78(6):1504-1512. PubMed 2431001Blum WF, Ranke MB, Kietzmann K, Gauggel E, Zeisel HJ, Bierich JR. A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: Its use for diagnosis of GH deficiency.

J Clin Endocrinol Metab.

1990 May; 70(5):1292-1298.PubMed 1692331

Insulin-like Growth Factor Binding Protein-3 on the IDS iSYS, Device Code IS-4400, IFU Version 2011-11-29 V03.

Fountain Hills, Ariz:Immunodiagnostic Systems Inc (IDS Inc).Rosenfeld RG, Wilson DM, Lee PD, Hintz RL.. Insulin-like growth factors I and II in evaluation of growth retardation.

J Pediatr.

1986 Sep; 109(3):428-433. PubMed 3746530